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Thirty-three tumors (33%) were diffusely positive for the antigen, as judged by distribution on the entire cell surface. Immunoreactivity was most intense in the cytoplasm and plasma membrane. Twenty-four of the 66 patients with tumors were treated with a combination of cisplatin and etoposide. Immunoreactivity of CD38 was higher in patients treated with this regimen than in those treated with cisplatin alone. When the difference in the degree of immunoreactivity was compared between patients with germ cell tumors and patients with non-germ cell tumors, the former showed significantly higher immunoreactivity of CD38 than the latter. Analysis of the association of the clinical stage of the disease with the degree of immunoreactivity revealed that in cases where a patient had either disseminated disease or low-stage disease, the expression of CD38 was markedly decreased. In two of three cases in which metastatic disease developed subsequently, the expression of CD38 was enhanced in two of the three cases. These results indicate that the expression of CD38 is associated with the malignancy and clinical course of germ cell tumors.[Intravenous immunoglobulin therapy for Guillain-Barré syndrome]. Guillain-Barré syndrome is a distinct form of acute inflammatory polyradiculoneuropathy that affects 1.5 per 100,000 persons annually. Typically, patients present with a progressive flaccid paralysis, are weak and experience reduced muscle strength, followed by gradual improvement with associated recovery of physical functions. The disorder is most commonly triggered by an infection, but other predisposing factors, such as pregnancy, are reported. The prognosis is generally favorable, but it is important to be vigilant, as the condition can be fatal. 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